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Key clinical features include: Progressive exertional dyspnea the cardinal symptom, initially on exertion and advancing to rest in severe disease Dry, nonproductive cough persistent and often refractory to standard antitussives Bibasilar inspiratory crackles (Velcro crackles) present in ~80% of IPF patients on auscultation Digital clubbing present in up to 50% of IPF cases

Koszowski and colleagues (2018) found a mean pH for large cigar tobacco filler of 6.53, which did not notably differ from the cigarillos

Canada was the first to adopt graphic warnings in 2001, using images like rotten teeth and red eyes with texts like When you smoke it shows to cover 50% of the front and back of cigarette packs

Teen Ambassadors are saying about vaping and their thoughts on addiction